From ScienceDaily@1337:3/111 to All on Tue Nov 23 21:30:38 2021
Aspirin is linked with increased risk of heart failure in some
November 23, 2021
European Society of Cardiology
Aspirin use is associated with a 26% raised risk of heart failure
in people with at least one predisposing factor for the condition.
FULL STORY ========================================================================== Aspirin use is associated with a 26% raised risk of heart failure in
people with at least one predisposing factor for the condition. That's
the finding of a study published today in ESC Heart Failure, a journal of
the European Society of Cardiology (ESC).1 Predisposing factors included smoking, obesity, high blood pressure, high cholesterol, diabetes,
and cardiovascular disease.
========================================================================== "This is the first study to report that among individuals with a
least one risk factor for heart failure, those taking aspirin were
more likely to subsequently develop the condition than those not using
the medication," said study author Dr. Blerim Mujaj of the University
of Freiburg, Germany. "While the findings require confirmation, they
do indicate that the potential link between aspirin and heart failure
needs to be clarified." The influence of aspirin on heart failure is controversial. This study aimed to evaluate its relationship with heart
failure incidence in people with and without heart disease and assess
whether using the drug is related to a new heart failure diagnosis in
those at risk.
The analysis included 30,827 individuals at risk for developing heart
failure who were enrolled from Western Europe and the US into the
HOMAGE study. "At risk" was defined as one or more of the following:
smoking, obesity, high blood pressure, high cholesterol, diabetes and cardiovascular disease. Participants were aged 40 years and above and
free of heart failure at baseline. Aspirin use was recorded at enrolment
and participants were classified as users or non- users. Participants
were followed-up for the first incidence of fatal or non- fatal heart
failure requiring hospitalisation.
The average age of participants was 67 years and 34% were women. At
baseline, a total of 7,698 participants (25%) were taking aspirin. During
the 5.3-year follow-up, 1,330 participants developed heart failure.
The investigators assessed the association between aspirin use and
incident heart failure after adjusting for sex, age, body mass index,
smoking, alcohol use, blood pressure, heart rate, blood cholesterol, creatinine, hypertension, diabetes, cardiovascular disease, and treatment
with renin-angiotensin- aldosterone-system inhibitors, calcium channel blockers, diuretics, beta- blockers and lipid-lowering drugs. Taking
aspirin was independently associated with a 26% raised risk of a new
heart failure diagnosis.
To check the consistency of the results, the researchers repeated the
analysis after matching aspirin users and non-users for heart failure
risk factors. In this matched analysis, aspirin was associated with
a 26% raised risk of a new heart failure diagnosis. To check the
results further, the analysis was repeated after excluding patients
with a history of cardiovascular disease. In 22,690 participants (74%)
free of cardiovascular disease, aspirin use was associated with a 27%
increased risk of incident heart failure.
Dr. Mujaj said: "This was the first large study to investigate the
relationship between aspirin use and incident heart failure in individuals
with and without heart disease and at least one risk factor. Aspirin
is commonly used -- in our study one in four participants were taking
the medication. In this population, aspirin use was associated
with incident heart failure, independent of other risk factors."
He concluded: "Large multinational randomised trials in adults at risk
for heart failure are needed to verify these results. Until then, our observations suggest that aspirin should be prescribed with caution
in those with heart failure or with risk factors for the condition." ========================================================================== Story Source: Materials provided by European_Society_of_Cardiology. Note: Content may be edited for style and length.
========================================================================== Journal Reference:
1. Blerim Mujaj, Zhen‐Yu Zhang, Wen‐Yi Yang, Lutgarde
Fang‐Fei Wei, Peter Verhamme, Christian Delles, Javed Butler,
Peter Sever, Roberto Latini, John GF Cleland, Faiez Zannad, Jan
Aspirin use is associated with increased risk for incident heart
failure: a patient‐level pooled analysis. ESC Heart Failure,
2021; DOI: 10.1002/ehf2.13688 ==========================================================================